Expression Regulation, Protein Chemistry and Functional Biology of the Guanine-Rich Sequence Binding Factor 1 (GRSF1)

Bernhard Dumoulin,Christoph Ufer,Hartmut Kuhn,Sajad Sofi

Journal of Molecular Biology（2021）

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摘要

•GRSF1 binds to Guanin rich strands of RNA and regulates erythropoiesis, redox homeostasis and cellular senescence.•GRSF1 plays a crucial role in mitochondrial RNA procession, ribosomal biogenesis and RNA degradation.•GRSF1 is involved in Influenza virus replication and regulates different HIV mRNAs.•GRSF1 promotes a malignant phenotype in cervical cancer through microRNA regulation.

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关键词

gene expression regulation,RNA-binding proteins,redox homeostasis,embryogenesis,hematopoiesis

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