Human chondroblastoma cell line and application thereof

The invention relates to a human chondroblastoma cell line and application thereof. The preservation number of the human chondroblastoma cell line is CCTCC NO: C2020110, the donor of the human chondroblastoma cell line is from a clinical histone H3.3K36M mutation chondroblastoma patient, lysine at the 36 site on H3F3B is mutated into methionine gene mutation, osteogenesis, chondrogenesis and adipogenesis are hindered in differentiation, and the human chondroblastoma cell line has tibia in-situ tumorigenesis capacity and stable tumorigenesis capacity, can be transfected by lentivirus and has a gene modification function. The human chondroblastoma cell line can be applied to screening of drugs for treating chondroblastoma, construction of drug-resistant chondroblastoma models, construction of chondroblastoma animal models, screening of chondroblastoma related biomarkers and research of the occurrence and development mechanism of chondroblastoma. The invention provides experimental materials for researchers to deeply develop the occurrence and development mechanism of chondroblastoma and find or evaluate treatment schemes.