Influence of BRAF and PIK3CA mutations on the efficacy of FOLFIRI plus bevacizumab or cetuximab as first-line therapy in patients with RAS wild-type metastatic colorectal carcinoma and <3 baseline circulating tumour cells: the randomised phase II VISNÚ-2 study

•This study examined if BRAF/PIK3CA mutational status can guide therapy in RAS wild-type mCRC.•BRAF mutations were associated with poorer survival outcomes, and were potentiated by PI3KCA mutations.•Bevacizumab-FOLFIRI versus cetuximab-FOLFIRI had similar outcomes in BRAF /PIK3CA wild-type and BRAF /PIK3CA-mutated tumours.•BRAF and PI3KCA mutations have a role as prognostic but not predictive factors.