Cardiovascular magnetic resonance stress and rest T1-mapping using regadenoson for detection of ischemic heart disease compared to healthy controls

•Regadenoson has advantages over adenosine in terms of administration, safety profile, and clinical workflow.•There are distinct tissue characteristics for normal, ischemic, infarcted, and remote myocardium.•Healthy controls demonstrate significant stress T1 reactivity during vasodilator stress.•Regadenoson stress T1-mapping can distinguish between different myocardial tissue classes.•Regadenoson stress T1-mapping is a viable alternative to adenosine and exercise for the assessment of coronary artery disease.