Novel simultaneous method for the determination of avobenzone and oxybenzone in human plasma by UHPLC-MS/MS with phospholipid removal pretreatment: An application to a sunscreen clinical trial

Nageswara R Pilli,Suresh Narayanasamy,Jeffry Florian,Robbert Zusterzeel,Vikram Patel,David G Strauss,Murali K Matta

Journal of Chromatography B（2021）

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摘要

•Sensitive and simultaneous determination of sunscreen active ingredients avobenzone and oxybenzone in plasma.•First UHPLC-MS/MS report for the determination of avobenzone and oxybenzone in human plasma.•High-throughput sample preparation using Phree Phospholipid removal 96-well protein precipitation.•Application to a sunscreen clinical study.

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关键词

Avobenzone,Oxybenzone,Phospholipid removal pretreatment,LC–MS/MS analysis,Sunscreen clinical study

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