阿德福韦酯治疗慢性乙型肝炎致Fanconi综合征2例报告并文献复习
Chinese Journal of Practical Internal Medicine（2014）
Abstract
慢性乙型肝炎病毒(hepatitis B virus,HBV)感染是严重的全球公共卫生问题[1-2].核苷(酸)类似物是可以有效控制HBV复制的一类药物.随着阿德福韦酯在治疗慢性HBV感染中使用,用药人群的不断扩大、用药时间延长,不但要监测其常见的轻度肾毒性,还要监测少见、严重肾毒性.与替诺福韦相似,阿德福韦酯造成的严重肾小管损伤可表现为Fanconi综合征.患者常就诊于风湿免疫科、骨科、内分泌科、肾内科等科室,经过多种检查,接受各种治疗甚至激素、细胞毒药物等,不但使患者受尽痛苦、且浪费大量医疗资源.
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