Quantitative Imaging Metrics Derived From Magnetic Resonance Fingerprinting Using Ismrm/Nist Mri System Phantom: An International Multicenter Repeatability And Reproducibility Study

Purpose To compare the bias and inherent reliability of the quantitative (T-1 and T-2) imaging metrics generated from the magnetic resonance fingerprinting (MRF) technique using the ISMRM/NIST system phantom in an international multicenter setting.Method ISMRM/NIST MRI system phantom provides standard reference T-1 and T-2 relaxation values (vendor-provided) for each of the 14 vials in T-1 and T-2 arrays. MRF-SSFP scans repeated over 30 days on GE 1.5 and 3.0 T scanners at three collaborative centers. MRF estimated T-1,T- and T-2 values averaged over 30 days were compared with the phantom vendor-provided and spin-echo (SE) based convention gold standard (GS) method. Repeatability and reproducibility were characterized by the within-case coefficient of variation (wCV) of the MRF data acquired over 30 days, along with the biases.Result For the wide ranges of MRF estimated T-1 values, vials #1-8 (T-1 relaxation time between 2033 and 184 ms) exhibited a wCV less than 3% and 4%, respectively, on 3.0 and 1.5 T scanners. T-2 values in vials #1-8 (T-2 relaxation, 1044-45 ms) have shown wCV to be <7% on both 3.0 and 1.5 T scanners. A stronger linear correlation overall for T-1 (R-2 = 0.9960 and 0.9963 at center-1 and center-2 on 3.0 T scanner, and R-2 = 0.9951 and 0.9988 at center-1 and center-3 on 1.5 T scanner) compared to T-2 (R-2 = 0.9971 and 0.9972 at center-1 and center-2 on 3.0 T scanner, and R-2 = 0.9815 and 0.9754 at center-1 and center-3 on 1.5 T scanner).Bland-Altman (BA) analysis showed MRF based T-1 and T-2 values were within the limit of agreement (LOA) except for one data point. The mean difference or bias and 95% lower bound (LB) and upper bound (UB) LOA are reported in the format; mean bias: 95% LB LOA: 95% UB LOA. The biases for T-1 values were 21.34: -50.00: 92.69, 21.32: -47.29: 89.94 ms, and for T-2 values were -19.88: -42.37: 2.61, -19.06: -43.58: 5.45 ms on 3.0 T scanner at center-1 and center-2, respectively. Similarly, on 1.5 T scanner biases for T-1 values were 26.54: -53.41: 106.50, 9.997: -51.94: 71.94 ms, and for T-2 values were -23.84: -135.40: 87.76, -37.30: 134.30: 59.73 ms at center-1 and center-3, respectively. Additionally, the correlation between the SE based GS and MRF estimated T-1 and T-2 values (R-2 = 0.9969 and 0.9977) showed a similar trend as we observed between vendor-provided and MRF estimated T-1 and T-2 values (R-2 = 0.9963 and 0.9972). In addition to correlation, BA analysis showed that all the vials are within the LOA between the GS and vendor-provided for the T-1 values and except one vial for T-2. All the vials are within the LOA between GS and MRF except one vial in T-1 and T-2 array.The wCV for reproducibility was <3% for both T-1 and T-2 values in vials #1-8, for all the 14 vials, wCV calculated for reproducibility was This study shows that MRF is highly repeatable (wCV <4% for T-1 and <7% for T-2) and reproducible (wCV < 3% for both T-1 and T-2) in certain vials (vials #1-8).