The role of Tetrahydrocannabinol in inducing disrupted signaling cascades, hippocampal atrophy and memory defects

Elahe Barfi,Ava Modirzadeh Tehrani, Mojtaba Mohammadpanah,Mahdi Eskandarian Boroujeni,Gholam Hossein Meftahi,Yousef Sadeghi, Samira Eziy,Aysan Khatmi,Mohammad Amin Abdollahifar,Zeynab Ghorbani,Abbas Aliaghaei

Journal of Chemical Neuroanatomy（2021）

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摘要

•THC administration interrupts long term memory and long term potentiation.•Stereological studies revealed considerable atrophy in hippocampus.•Several signaling cascades related to synaptic regulation were interrupted in hippocampus under THC administration.

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Tetrahydrocannabinol,Hippocampus,Neurodegeneration,RNA-seq

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