A Ser252Trp substitution in mouse FGFR2 results in hyperplasia of embryonic salivary gland parenchyma

Tsukasa Watanabe,Kaori Kometani-Gunjigake,Kayoko Nakao-Kuroishi,Misa Ito-Sago,Masahiro Mizuhara, Daiki Iwata,Keiji Moriyama,Kentaro Ono,Tatsuo Kawamoto

Journal of Oral Biosciences（2021）

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摘要

•An S252W substitution in FGFR2 causes hyperplasia of the salivary gland parenchyma.•An S252W mutation in FGFR2 promotes FGFR1 expression in the salivary gland at E15.5.•An S252W substitution in FGFR2 promotes apoptosis in the salivary gland at E15.5.

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关键词

Embryo Development,Submandibular gland,Apert Syndrome,FGF Receptors,Morphogenesis

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