DNA building blocks for AFM tip functionalization: An easy, fast and stable strategy

Michael Leitner, Julian Brummeir, Gernot Oswald Plaimer, Isabel Kefer,Alexandra Poturnayova,Tibor Hianik,Andreas Ebner

Methods（2022）

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摘要

•DNA Tetrahedra are suited as AFM crosslinker.•Dip and measure tip chemistry for biosensing AFM gets possible.•New tip chemistry allows fast and efficient binding of ligands to the AFM tip.•DNA tetrahedra tip chemistry gives accurate rupture length.•DNA tetrahedra are optimal suited for DNA aptamers.

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关键词

Molecular biosensors,Single molecule,AFM,Tip chemistry,DNA tetrahedra,Force spectroscopy,Tip functionalization,DNA building blocks

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