Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries

•A new integrated risk tool combines clinical and polygenic risk scores.•Prediction is significantly enhanced in multiple ethnicities and ancestries.•Ethnicities include Black and White, ancestries include African and European.•This is the first positive cross-ethnicity cross-ancestry validation of such a tool.