Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition

•This is the first long-term (1-year) study to evaluate both the kidney and systemic sequelae of acute kidney injury in mice.•Serial kidney function was measured via transcutaneous glomerular filtration rate.•AKI resulted in diastolic dysfunction, followed by hypertension. Ejection fraction was preserved. One year after AKI, cardiac ATP levels were reduced compared with sham controls.•Mice treated with the histone deacetylase inhibitor, ITF2357, maintained normal diastolic function normal blood pressure, and normal cardiac ATP after AKI.•Metabolomics data suggest that treatment with ITF2357 preserves pathways related to energy metabolism.