Peripheral blood cultured mast cells: Phenotypic and functional outcomes of different culture protocols

Jessy Elst,Vito Sabato,Marie-Line M van der Poorten,Margaretha Faber,Athina L Van Gasse,Leander P De Puysseleyr,Chris H Bridts,Christel Mertens,Michel Van Houdt,Marcus Maurer,Margo M Hagendorens,Didier G Ebo

Journal of Immunological Methods（2021）

引用 9|浏览5

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摘要

•Primary human mast cells can be cultured in a four-week culture system.•IL-6 increases the mast cell yield and improves functionality.•The mast cells enable exploration of sIgE/FceRI- and MRGPRX2-dependent activation.

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关键词

IgE,Human mast cell,MRGPRX2,IgE-dependent activation,Mast cell activation,Flow cytometry

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