A cascade reaction for the synthesis of d-fagomine precursor revisited: Kinetic insight and understanding of the system

Martina Sudar,Morana Česnik,Pere Clapés,Martina Pohl,Đurđa Vasić-Rački,Zvjezdana Findrik Blažević

New Biotechnology（2021）

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摘要

•Synthesis of a precursor of a dietary supplement iminosugar d-fagomine was studied.•Kinetic model of a three-enzyme cascade was developed.•The validated mathematical model enabled improvement of the product yield.

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关键词

c,d,Ki,kd,Km,MM,r1,r2,r3,r4,r5,r6,S.A.,t,V.A.,Venz,Vm,Vr,X,Y,ε340,γ,aldol adduct,amino acid,amino alcohol,amino aldehyde,DHA,FSA,TEA HCl,TFA

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