Antibiotic exposure decreases soil arsenic oral bioavailability in mice by disrupting ileal microbiota and metabolic profile

•Soil and antibiotic co-exposure reshaped mouse gut microbiota and metabolic profile.•Antibiotic co-exposure decreased As accumulation in mouse kidneys and excretion in urine.•Soil bioavailable As pool in the intestinal tract decreased due to reduced amino acids.•Transformation from inorganic to organic As was enhanced by the antibiotic perturbed microbiota.•Gut microbiota and metabolites played an important role in soil-borne As bioavailability.