Enhancing Artemisinin Solubility in Aqueous Solutions: Searching for Hydrotropes based on Ionic Liquids

•The hydrotropic effect of ILs on the aqueous solubility of artemisinin was studied.•Cooperative hydrotropy model were used to describe artemisinin solubility.•Apolarity and hydrogen-bond acceptor character of hydrotrope important for solubility enhancement.•Solvatochromic parameters of the ILs aqueous solutions were measured.•Solubility enhancement correlates well with solvent polarizability.