ModFlex: Towards Function Focused Protein Modeling

Mayya Sedova,Lukasz Jaroszewski,Mallika Iyer,Zhanwen Li,Adam Godzik

Journal of Molecular Biology（2021）

引用 2|浏览6

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摘要

•Homology modeling method uses known protein structures as templates.•Templates are often chosen based on their sequence identity to the target.•Structures of the same protein often change between functional states.•Template most similar to the target is not always an optimal choice.•Interactive visual analysis in ModFlex improves template selection.

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关键词

homology-based modeling,structure modeling,structure prediction,structural flexibility,functional substates

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