Significant elevation of free itraconazole concentration at onset of adverse effects: A case report

Ryota Tanaka,Yosuke Suzuki,Hiroyuki Matsumoto,Mari Yamasue,Kenji Umeki,Kazuhiko Hashinaga,Ryosuke Tatsuta,Kazufumi Hiramatsu,Katsuhiko Kamei,Jun-ichi Kadota,Hiroki Itoh

CLINICAL CASE REPORTS（2021）

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摘要

Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.

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adverse effects,free concentration,hydroxyitraconazole,Itraconazole,therapeutic drug monitoring

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