Design, synthesis, biological evaluation and molecular modeling investigation of new N'-(2-Thiouracil-5-oyl) hydrazone derivatives as potential anti-breast cancer and anti-bacterial agents
Journal of Molecular Structure(2021)
摘要
•Thiouracil derivatives are precursor for anticancer activity.•Pseudomonas aeruginosa is an important cause of persistent infections due to its acquired multidrug resistance, its virulence factors and its biofilms form.•Thiouracil derivatives are recently used as antibiofilm and antivirulence activities.
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关键词
Pyrimidinones,Thiouracil derivatives,N’-(2-thiouracil-5-oyl)hydrazones,Anticancer and antibacterial agents,Molecular modeling,ADME prediction
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