Physico-Chemical and Microbiological Study for the Stability of Phenytoin Sodium Extemporaneously Compounded Suspension in Saudi Arabia Hospitals

Epilepsy\r\nis a chronic and the fourth most common neurological disorder which affects\r\npeople of all age groups. Recently research and awareness on epilepsy-related\r\ndeaths have rapidly grown over the past two decades. Many previous studies are\r\nattributed to the guidelines that apprise health care professionals in handling\r\nthese deaths, but there is a relative scarcity of information accessible for clinicians\r\nand pharmacists who are responsible for manufacturing or preparing the\r\nextemporaneous anti-epileptic suspensions in the hospitals. Mostly in partial\r\nseizures, phenytoin is one of the first-choice drugs. In Saudi Arabian\r\nhospitals, the extemporaneous preparation of phenytoin suspension is common,\r\nbut the hot climatic weather in Saudi Arabia possesses stability problems that\r\nshould be tackled as the prepared suspension should pass all the stability\r\ntests to ensure uniform dosage of the extemporaneous formulation. In the\r\ncurrent study, the commercial capsules were used to prepare the oral phenytoin\r\nsodium extemporaneous suspension. The physical, chemical and microbiological\r\nstability of phenytoin sodium suspension is analyzed at various temperatures.