Enzyme-responsive polysaccharide supramolecular nanoassembly for enhanced DNA encapsulation and controlled release

An enzyme-responsive polysaccharide supramolecular targeted nanoassembly composed of positively charged mono-(6-(tetraethylenepentamine)-6-deoxy)-β-cyclodextrin (TEPA-CD) and adamantane-grafted hyaluronic acid (HA-ADA) was constructed, possessing controlled DNA condensation and exhibited lower cytotoxicity than the commercial transfection reagent 25 kDa bPEI (PEI25k), accompanied by similar gene delivery effect.