Development Of A Novel Method For Trimethylsilylation Of Saccharides

The trimethylsilyl (TMS) group is widely used in carbo-hydrate synthesis, although this protecting group is unstable and its post-synthetic purification challenging. The successful trimethylsilyl-ation of carbohydrates mediated by recyclable and efficient acidic catalyst PTA/HMDS and the novel reagent, TMSOAc (TEA/TMSOAc), under alkaline condition is reported. The advantages of these methods are that the reactions proceed in good to excellent yields without applying column chromatography for purification.