Propofol In Preterm Neonates

In their prospepective study in very preterm neonates, De Kort et al. analysed the effects of different propofol starting doses as premedication for endotracheal intubation on blood pressure (1.0 mg/kg (n = 30), 1.5 mg/kg (n = 23) or 2.0 mg/kg (n = 26)) [1]. The authors demonstrated that propofol caused a dose-dependent profound and protracted drop in blood pressure which was mainly dependent on the initial propofol starting dose rather than the cumulative propofol dose.