Total Synthesis Of Alstofonidine Via Its Putative Biosynthetic Congener

A first total synthesis of alstofonidine is described from the pentacyclic core, an advanced intermediate reported previously. The pentacyclic core facilitated putative biosynthetic congener access, thereby allowing a rapid synthesis of alstofonidine from the proposed biosynthetic pathway. Besides, the model substrate to obtain a simplified bicyclic acetal portion also leveraged in accomplishing structurally complex alstofonidine effortlessly. (C) 2021 Elsevier Ltd. All rights reserved.