The beneficial effects of taurine in alleviating fatty liver disease

Qi Song,Junxia Guo,Yanzhen Zhang,Wen Chen

Journal of Functional Foods（2021）

引用 11|浏览2

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摘要

•Taurine is considered to have great potential in development of functional foods.•Its alleviating effects on AFLD/NAFLD can be derived from in vivo/in vitro data.•It prevents liver steatosis by inhibiting lipogenesis/promoting energy expenditure.•It prevents oxidative damage by inhibiting ROS/stabilizing mitochondrial membrane.•It prevents inflammation by inhibiting TLR-4 mediated signaling pathways.

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关键词

ACC,ACOX,ADH,ALDH,AMPK,AFLD,Bcl-2,CAT,ChREBP,COX,COX-2,CRP,CYP2E1,CYP7A1,FAS,FasL,FFA,FLD,FXR,GSH,GSSG,GSH-Px,H&E,HMGCR,HNF4α,HO-1,HSCs,iNOS,IκB,JNK,Keap1,LDLR,LPO,LPS,LXRα,MAPK,MEK,MDA,MyD88,NAFLD,ND,NF-κB,NO,Nrf2,O2–•,p-c-Jun,p-ERK1/2,p-P38,PGC1α,PPARα,PRX,ROS,SCD,Sirt1,SOD,SREBP-1c,T-AOC,TauBr,TauCl,TBARS,TC,TG,TGFB1,TLR-4,TRX,TUDCA,UCP2

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