Bortezomib enhances G-CSF-induced hematopoietic stem cell mobilization by decreasing CXCL12 levels and increasing vascular permeability

Taichi Matsumoto,Yasushi Takamatsu, Hanae Moriyama,Kazuki Terada,Masayoshi Mori,Kazuhiko Ono,Keisuke Migita,Shuuji Hara

Experimental Hematology（2021）

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摘要

•BTZ injection the night before blood collection is effective for HSPC mobilization.•BTZ injection 3 days before blood collection adversely abrogated G-CSF-induced HSPC mobilization.•BTZ did not affect VLA-4 expression on HSPCs and VCAM-1 expression on BMSCs.•BTZ lowered CXCL12 chemokine expression in the bone marrow.•BTZ increased vascular permeability to further enhance HSPC mobilization.

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关键词

CXCL12,VCAM-1,VLA-4,bortezomib,granulocyte colony-stimulating factor,hematopoietic stem cell transplantation,mobilization,vascular hyperpermeability

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