Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines.

C H Cole Sims,Matias I Autio,Adriana Buskin,Christine Cheung,Rakesh Heer,Roger S Y Foo,Xin Wang

Stem cell research（2021）

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摘要

Two cell lines were generated by CRISPR/Cas9 mediated knockout of MKK7 (MAP2K7) by removal of exon 1 or exons 4 through 7. These knockouts were confirmed at the transcript and protein levels. These hESCs are pluripotent and maintain tri-lineage differentiation capacity. These cell lines are a useful resource for studying MKK7 function in humans.

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