Adipose tissue estrogen production and metabolism in premenopausal women

Natalia Hetemäki,Tomi S Mikkola,Matti J Tikkanen,Feng Wang,Esa Hämäläinen,Ursula Turpeinen,Mikko Haanpää,Veera Vihma,Hanna Savolainen-Peltonen

The Journal of Steroid Biochemistry and Molecular Biology（2021）

引用 29|浏览5

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摘要

•Estrone is the dominant adipose tissue estrogen in premenopausal women.•Estrone levels in adipose tissue are much higher than in the circulation.•Adipose tissue converts estrone sulfate to estrone, and estrone to estradiol.•Waist circumference correlates with higher estradiol production in subcutaneous fat.

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17β-HSD,AT,BMI,cDNA,DHEA,DHEAS,E1,E1S,E2,IS,LC–MS/MS,LOQ,mRNA,PCR,SHBG,STS

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