Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project
Journal of Affective Disorders（2021）
摘要
•A novel quantitative measure reflecting functional connectivity asymmetry of brain was employed.•The largest resting-state fMRI dataset of major depressive disorder in China was used.•Many brain networks contribute to broad clinical pathophysiology of MDD.•A lateralized, efficient and economical brain information processing system is disrupted in MDD.
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关键词
Major depressive disorder,hemispheric asymmetry,parameter of asymmetry,fMRI Abbreviations ACC, Anterior cingulate gyrus,DLPFC, Dorsolateral prefrontal cortex,DMN, Default mode network,DPARSF, Data Processing Assistant for Resting-State fMRI,DSM, Diagnosic and Statistical Manual of Mental Disorders,EEG, Electroencephalographic,FC, Functional connectivity,FDR, False discovery rate,FEDN, First-episode, drug-naive,FEF, Frontal eye fields,fMRI, Functional magnetic resonance imaging,HAMD, Hamilton Depression Rating Scale,HC, Healthy control,IFG, Inferior frontal gyrus,IPL, Inferior parietal lobule,IPS/SPL, Intraparietal sulcus/superior parietal lobule,LMM, Linear mixed model,MDD, Major depressive disorder,MFG, Middle frontal gyrus,MTG, Middle temporal gyrus,PAS, Parameter of asymmetry,PCC, Posterior cingulate cortex,PET, Positron emission tomography,ROIs, Regions of interest,rs-fMRI, Resting-state fMRI,rTMS, repetitive transcranial magnetic stimulation,STS, Superior temporal sulcus,VMHC, Voxel-mirrored homotopic connectivity
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