Role of α2δ3 in Cellular Synchronization of the Suprachiasmatic Nucleus Under Constant Light Conditions

Masahiro Matsuo,Kazuyuki Seo,Naoki Mizuguchi,Fumiyoshi Yamazaki,Shoichi Urabe,Naoto Yamada,Masao Doi,Keiko Tominaga,Hitoshi Okamura

Neuroscience（2021）

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摘要

•A synaptic molecule α2δ3 was strongly expressed in suprachiasmatic nucleus (SCN).•Intercellular synchrony was impaired in cultured SCN in Cacna2d3 knockout mice.•Cacna2d3 KO mice show weakened locomotor activity rhythms under constant light.•α2δ3 is essential for synchronized cellular rhythms important to behavior rhythms.

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关键词

CT,EDTA,rPSD,SCN

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