Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis

•Omentin-1 serves as a novel biomarker for predicting the functional outcome of acute ischemic stroke, and low circulating omentin-1 level indicates high risk of ischemic stroke.•Elevated omentin-1 level could attenuate atherosclerosis and exert a favorable impact on cerebral ischemia.•Omentin-1 has benefical effects on vascular inflammation and dysfunction through various signaling pathways.•Metformin and statins together with omentin-1 have great potential to be developed into novel drug therapy against ischemic stroke.