Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma.

Axel H Schönthal,David M Peereboom,Naveed Wagle,Rose Lai,Anna J Mathew,Kyle M Hurth,Vincent F Simmon,Steven P Howard,Lynne P Taylor,Frances Chow,Clovis O da Fonseca,Thomas C Chen

Neuro-oncology advances（2021）

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摘要

Intranasal glioma therapy with NEO100 was well tolerated. It correlated with improved survival when compared to historical controls, pointing to the possibility that this novel intranasal approach could become useful for the treatment of recurrent GBM.

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关键词

O6-methylguanine-DNA methyltransferase,intranasal,isocitrate dehydrogenase 1,perillyl alcohol,recurrent glioblastoma

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