Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI.

Guixian Tang,Pan Chen,Guanmao Chen,Shuming Zhong,JiaYing Gong,Hui Zhong,Tao Ye,Feng Chen,Jurong Wang,Zhenye Luo,Zhangzhang Qi,Yanbin Jia,Ying Wang,Li Huang

Psychological medicine（2021）

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摘要

Our findings that serum IL-8 levels are associated with impaired FC in the right precentral gyrus in BD II patients suggest that inflammation might play a crucial role in brain functional abnormalities in BD.

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关键词

Bipolar disorder,functional connectivity,functional magnetic resonance imaging,inflammation,interleukin-8,orbitofrontal cortex,precentral gyrus

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