Nivolumab-Caused Hyperprogression Of Diffuse Large B-Cell Lymphoma Of The Testis And Spontaneous Remission Of Type 2 Diabetes Mellitus In An Elderly Patient: A Case Report

Nivolumab has been used in a variety of advanced malignant tumors. Cases of autoimmune diabetes associated with Nivolumab therapy have been reported gradually in recent years. This article reported a case of primary testicular lymphoma in an elderly patient with type 2 diabetes mellitus (T2DM). After treatment with Nivolumab, the primary disease was hyperprogressive disease but the blood glucose was relieved for a long time. Nivolumab may relieve the previous T2DM in diffuse large B-cell lymphoma patients; the potential mechanism needs to be further explored.