Axonal damage and behavioral deficits in rats with repetitive exposure of the brain to laser-induced shock waves: Effects of inter-exposure time

Kosuke Miyai,Satoko Kawauchi,Tamaki Kato,Tetsuo Yamamoto, Yasuo Mukai,Taisuke Yamamoto,Shunichi Sato

Neuroscience Letters（2021）

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摘要

•Repeated brain exposure to shock waves is examined by laser-induced shock waves.•Behavioral impairments and axonal injury are worsened by repeated exposure.•Injury accumulation effects are suppressed with an inter-exposure period of 7 days.•A sufficiently long intermission is important for avoiding accumulation effects.

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关键词

Repetitive blast-induced traumatic brain injury,Inter-Exposure time,Laser-Induced shock wave,Axonal injury,motor dysfunction,Anxiety

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