A comparison of HER2/neu accumulations of Ga-67-labeled anti-HER2 antibody with chemically and site-specifically conjugated bifunctional chelators

Yumiko Kono,Keita Utsunomiya,Naoki Kan,Yohei Matsumoto,Yoshiko Sakata,Yuta Ohira,Hirokazu Satoh, Katsushi Koda,Tadashi Matsuura,Noboru Tanigawa

Cancer treatment and research communications（2021）

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摘要

•The site-specific binding (SSC) method can bind cytotoxic substances uniformly to mAb.•Pharmacokinetics of RI-labeled mAb using SSC differs from those of conventional methods.•The SSC method increases the retention rate of mAb and improves a tumor accumulation.

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关键词

Drug targets,Site-specific conjugation,Immunotherapy,Radioisotopes,Pharmacokinetics

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