Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers

Letícia Adrielle Dos Santos,Pedro Germano de Góis Filho, Ana Maria Fantini Silva,João Victor Gomes Santos,Douglas Siqueira Santos, Marília Marques Aquino, Rafaela Mota de Jesus,Maria Luiza Dória Almeida,João Santana da Silva,Daniel M Altmann,Rosemary J Boyton,Cliomar Alves Dos Santos,Camilla Natália Oliveira Santos,Juliana Cardoso Alves, Ianaline Lima Santos,Lucas Sousa Magalhães, Emilia M M A Belitardo,Danilo J P G Rocha,João P P Almeida,Luis G C Pacheco,Eric R G R Aguiar,Gubio Soares Campos,Silvia Inês Sardi,Rejane Hughes Carvalho,Amélia Ribeiro de Jesus, Karla Freire Rezende,Roque Pacheco de Almeida

Journal of Infection（2021）

引用 105|浏览12

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摘要

•We describe 33 patients with recurrent COVID19 and a positive PCR.•Recurrence is associated with working as a healthcare professional, blood-group A, and low IgG response to infection.•Evidence from differential virus sequencing between the first and second episode supports de novo reinfection.•Recurrent episodes tended to be more severe, with one fatal infection.

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关键词

COVID-19,Recurrence,Reinfection,SARS-CoV-2,Antibodies

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