Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts

•Hypoxiaand inflammation are two critical factors that shape the periodontitis.•High levels of interleukin-1β can cause an HGF inflammatory response.•GSDMD-mediated pyroptotic plays an important role in the pathogenesis of periodontitis.•Hypoxia and P. gingivalis-LPS synergistically induced NLRP3 inflammasome activation.