Tc-99m-Cn7dg: A Highly Expected Spect Imaging Agent Of Cancer With Satisfactory Tumor Uptake And Tumor-To-Nontarget Ratios

A novel glucose derivative (CN7DG) possessing an isonitrile as a coordinating group was synthesized, and Tc-99m-CN7DG, which was expected to be a powerful tumor imaging agent for SPECT, was prepared in a kit by the reaction of CN7DG with SnCl2 center dot 2H(2)O and (TcO4-)-Tc-99m. Tc-99m-CN7DG exhibited good stability and was transported via glucose transporters. Biodistribution results in mice bearing A549 tumor models showed that Tc-99m-CN7DG had a higher uptake at the tumor sites and better tumor/blood and tumor/muscle ratios than did [F-18]FDG and Tc-99m-CN5DG. SPECT/CT imaging studies showed obvious accumulation in tumor sites, suggesting that Tc-99m-CN7DG is a promising candidate for tumor imaging. Because Tc-99m and Re-188 stand for a "theranostic pair", Re-188-CN7DG is expected to be prepared as a promising agent for tumor therapy.