Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment

•GMSCs-Exos inhibit the inflammatory response of M1 macrophages in a high-lipid microenvironment.•GMSCs-Exos reduce lipid accumulation in M1 macrophages in a high-lipid microenvironment.•Cell-free therapy with GMSCs-Exos may be a novel therapeutic strategy for periodontitis associated with hyperlipidemia.