Prognostic significance of transforming growth factor β receptor II in clinical stage III breast cancer patients - a pilot study.

Sherif Refaat,Sameh Shamaa,Tawfik Elkhodary, Nadia Atwan,Hayam Ghazy,Tamer Akl,Khaled Abdelwahab,Abd AlRahman Mohammad Foda,Adel El-Badrawy,Ziad Emarah

Breast disease（2021）

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摘要

These findings suggest the usage of therapeutic drugs that target TGFβ in advanced breast cancer patients may be effective. Nevertheless, blockage of the tumor promoting and sparing of the tumor suppressor effect of TGFβ pathway should be taken into consideration. We suggest that these therapies might have more benefit in ER and PR positive tumors.

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关键词

TβRII, transforming growth factor–β,breast cancer

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