The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients

Veronica Bordoni,Eleonora Tartaglia,Alessandra Sacchi,Gian Maria Fimia,Eleonora Cimini,Rita Casetti,Stefania Notari,Germana Grassi,Luisa Marchioni,Michele Bibas,Maria R Capobianchi,Franco Locatelli,Markus Maeurer,Alimuddin Zumla,Andrea Antinori,Emanuele Nicastri,Giuseppe Ippolito,Chiara Agrati

International Journal of Infectious Diseases（2021）

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摘要

•Significant reduction of SIRT1 in COVID-19 patients may play a role in the maintenance of p53 in the active form.•Significant increase of p21 in COVID-19 patients may participate to cell cycle arrest.•Inflammatory cytokines positively correlated with p53 and negatively with SIRT-1 and with BLNK expression.•The inflammation, the dysregulated p53/SIRT-1 axis and IL7R/BLNK expression may impact cell survival, B cell signaling in COVID-19 patients.

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关键词

COVID-19,p53/SIRT1,IL-7R,BLNK,Inflammation

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