Low-phospholipid-associated cholelithiasis syndrome: Prevalence, clinical features, and comorbidities

Catherine Dong,Bertrand Condat,Magalie Picon-Coste,Yves Chrétien,Pascal Potier,Béatrice Noblinski,Lionel Arrivé,Marie-Pierre Hauuy,Véronique Barbu,Anware Maftouh,Farid Gaouar,Karima Ben Belkacem,Chantal Housset,Raoul Poupon,David Zanditenas,Olivier Chazouillères,Christophe Corpechot

JHEP Reports（2021）

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摘要

•Low-phospholipid-associated cholelithiasis (LPAC) syndrome affects approximately 1% of adults with symptomatic cholelithiasis.•Normal weight, common bile duct stones, and lack of cholecystitis are clinical features significantly associated with this syndrome.•ABCB4 variants in patients with LPAC may be associated with an increased personal or family risk of hepato-biliary cancer.

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关键词

LPAC,ABCB4,Cholestasis,Pregnancy,Metabolic syndrome,Cancer

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