Increased Cholinergic Tone Causes Pre-synaptic Neuromuscular Degeneration and is Associated with Impaired Diaphragm Function

Matheus P.S. Magalhães-Gomes, Wallace Camargos,Priscila A.C. Valadão,Rubens S. Garcias,Hermann A. Rodrigues,Jéssica N. Andrade,Vanessa P. Teixeira,Lígia A. Naves,Walter L.G. Cavalcante, Marcia Gallaci,Silvia Guatimosim,Vânia F. Prado,Marco A.M. Prado,Cristina Guatimosim

Neuroscience（2021）

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摘要

•Increased VAChT expression augments post-synaptic response.•Hypercholinergic mice show endocytosis impairment and endplates degeneration.•Mice with increased VAChT expression show neurotransmission dysfunction.•The alterations herein observed recapitulate those seen in cholinesterase-treated patients.

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关键词

ACh,CMS,NMJs,PNS,VAChT,CNS,CHT1,ChAT

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