Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

Christina L. Hutson,Ashley V. Kondas,Mathew R. Mauldin,Jeffrey B. Doty,Irma M. Grossi,Clint N. Morgan,Sharon Dietz Ostergaard,Christine M. Hughes,Yoshinori Nakazawa,Chantal Kling,Brock E. Martin,James A. Ellison,Darin D. Carroll,Nadia F. Gallardo-Romero,Victoria A. Olson, John Schoggins

MSPHERE（2021）

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摘要

Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is highly transmissible, with an estimated 30% mortality.

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animal models,experimental therapeutics,monkeypox,smallpox,virology

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