Whole-brain activation signatures of weight-lowering drugs

Henrik H Hansen,Johanna Perens,Urmas Roostalu,Jacob Lercke Skytte,Casper Gravesen Salinas,Pernille Barkholt,Ditte Dencker Thorbek,Kristoffer T G Rigbolt,Niels Vrang,Jacob Jelsing,Jacob Hecksher-Sørensen

Molecular Metabolism（2021）

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摘要

•Whole-brain activation responses to six centrally acting weight-lowering drugs.•Overlapping drug responses in homeostatic and non-homeostatic feeding centres.•Identification of key neuroanatomical targets for future anti-obesity therapeutics.

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关键词

Imaging,iDISCO,Light sheet fluorescence microscopy,c-Fos,Obesity,Anti-Obesity drugs

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