Effect Of Obesity, Age And Gender On Glomerular Filtration Rate Measured In Normal Adults

The aims of this study were to assess the dependence of glomerular filtration rate (GFR) on age and gender and to produce reference data for the interpretation of Cr-51-EDTA GFR measurements in adults. Methods: This was a retrospective study of 120 live kidney donors (75 females, 45 males). GFR was evaluated from 51Cr-EDTA plasma clearance using blood samples taken at 3, 4 and 5 hours. The slope-intercept GFR was corrected for body surface area using the Dubois & Dubois and for the fast exponential using the BrochnerMortensen equation. Scatter plot of DFG against age in live kidney donors was plotted and the 98% range limits have been defined. Results: The median GFR obtained for kidney donors was 88 mL/min/1.73 m(2) [68-130]. No significant difference with genderwas found. 51Cr-EDTAclearancewas strongly correlated with patient age (r = - 0.62, P < 0,0001). GFR decreased by approximately 8 mL/min/1.73 m**(2) per decade. Based on these results, a nomogram for GFR is presented. Conclusion: The interpretation of GFR requires age-adjusted normal values. These standards need not be adjusted to the patient's sex or BMI.