Sodium propionate protect the blood-milk barrier integrity, relieve lipopolysaccharide-induced inflammatory injury and cells apoptosis

The schematic diagram representing the protective effect of propionate against LPS-induced deterioration to bMECs. LPS treatment down regulate tight junction proteins level, up-regulate oxidant and down-regulate antioxidant factors, which leads to activation of HDAC3 and mitochondrial dysfunction, and stimulates NF-kB signaling pathway, resulting bMEC damage. Propionate enhance tight junction integrity, improve antioxidant activity, and block NF-kB pathway, resulting in protection of bMECs from injury.Unlabelled Image