Evaluation of treatment, prognostic factors, and survival in 198 vulvar melanoma patients: Implications for clinical practice

•Vulvar melanoma is a rare gynaecological cancer with poor prognosis due to its high metastatic potential.•The only potentially curative option for localized disease is complete surgical resection with negative margins.•Sentinel lymph node biopsy is only recommended in order to direct adjuvant treatment.•Analysis for targetable mutations should be incorporated into routine clinical testing for vulvar melanoma.•Immunotherapy with anti-PD1 or anti-CTLA4 should be considered in metastatic or non-resectable vulvar melanoma.