Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus.

Sumathi Sivapalasingam, George A Saviolakis,Kirsten Kulcsar,Aya Nakamura,Thomas Conrad,Mohamed Hassanein,Giane Sumner,Chinnasamy Elango,Mohamed A Kamal, Simon Eng,Christos A Kyratsous,Bret J Musser,Matthew Frieman,Joel Kantrowitz,David M Weinreich,George Yancopoulos,Neil Stahl,Leah Lipsich

The Journal of infectious diseases（2022）

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摘要

REGN3048 and REGN3051 in combination were well tolerated. The clinical and preclinical data support further development for the treatment or prophylaxis of MERS-CoV infection.

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关键词

MERS,animal efficacy,first-in-human study,immunogenicity,monoclonal antibodies,pharmacokinetics,safety,tolerability

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